Risk Assessment in Large B-Cell Lymphoma Using Metabolic Tumor Volume: Real-World Data from a Multicenter Cohort of Patients Undergoing CAR T-Cell Therapy

Conrad-Amadeus Voltin, Sarah Flossdorf, Lars Kurch, Michael Winkelmann, Andrea Farolfi, Laura Beckmann, Beatrice Casadei, Ken Herrmann, Nadine Kutsch, Peter Borchmann, Matthias Brendel, Viktoria Blumenberg, Stefano Fanti, Pier Luigi Zinzani, Kambiz Rahbar, Gabriel T Sheikh, Osama Sabri, Alexander Drzezga, Markus Dietlein, H Christian Reinhardt, Wolfgang G Kunz, Jörn C Albring, Robert Seifert, Bastian von Tresckow, Jan-Michel Heger, Philipp Gödel, Marion Subklewe, Andrea Paccagnella, Vladan Vučinić, Christine Hanoun

J Nucl Med, 2026

MRD-2 in the GHSG HD21 trial assessed by a validated circulating tumor DNA sequencing assay

Jan-Michel Heger, Julia Mattlener, Helen Kaul, Justin Ferdinandus, Jessica Schneider, Julia K Schleifenbaum, Gundolf Schneider, Valdete Schaub, Mathias Hänel, Johannes C Hellmuth, Judith Dierlamm, Sonja Martin, Stephan Mathas, Julia Meissner, D Michiel Pegtel, Josée M Zijlstra, Anna Ossowski, Kerstin Becker, Michael Hallek, Bastian von Tresckow, Peter Borchmann, Sven Borchmann

Blood, 2026

Rapid molecular response kinetics to anti-PD-1-based first-line treatment of Hodgkin lymphoma in the GHSG NIVAHL trial

Jan-Michel Heger, Julia Mattlener, Peter Herhaus, Julia Meissner, Karolin Trautmann-Grill, Conrad-Amadeus Voltin, Jessica Schneider, Julia K Schleifenbaum, Sophie Heidenreich, Carsten Kobe, Helen Kaul, Wolfram Klapper, Bastian von Tresckow, Peter Borchmann, Paul J Bröckelmann, Sven Borchmann

Blood Adv, 2026

Glofitamab crosses the blood-brain barrier and exhibits activity against primary and secondary CNS lymphoma

Marie Anne-Catherine Neumann, Jessica Schneider, Max Szameitat, Philipp Schommers, Sven Borchmann, Michael Hallek, Peter Borchmann, Jan-Michel Heger

Blood Adv, 2026

The genomic and clinical consequences of replacing procarbazine with dacarbazine in escalated BEACOPP for Hodgkin lymphoma: a retrospective, observational study

Anna Santarsieri, Emily Mitchell, My H Pham, Rashesh Sanghvi, Janina Jablonski, Henry Lee-Six, Katherine Sturgess, Pauline Brice, Tobias F Menne, Wendy Osborne, Thomas Creasey, Kirit M Ardeshna, Joanna Baxter, Sarah Behan, Kaljit Bhuller, Stephen Booth, Nikesh D Chavda, Graham P Collins, Dominic J Culligan, Kate Cwynarski, Andrew Davies, Abigail Downing, David Dutton, Michelle Furtado, Eve Gallop-Evans, Andrew Hodson, David Hopkins, Hannah Hsu, Sunil Iyengar, Stephen G Jones, Mamatha Karanth, Kim M Linton, Oliver C Lomas, Nicolas Martinez-Calle, Abhinav Mathur, Pamela McKay, Sateesh K Nagumantry, Elizabeth H Phillips, Neil Phillips, John F Rudge, Nimish K Shah, Gwyneth Stafford, Alex Sternberg, Rachel Trickey, Benjamin J Uttenthal, Natasha Wetherall, Xiao-Yin Zhang, Andrew K McMillan, Nicholas Coleman, Michael R Stratton, Elisa Laurenti, Peter Borchmann, Sven Borchmann, Peter J Campbell, Raheleh Rahbari, George A Follows

Lancet Oncol, 2025

CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma

David Stahl, Philipp Gödel, Hyatt Balke-Want, Rahil Gholamipoorfard, Paul Segbers, Luis Tetenborg, Mirjam Koker, Janina Dörr, Lisa Gregor, Daniel Bachurski, France Rose, Adrian G Simon, Zinaida Good, Josefine Jakob, Björn Häupl, Marieke Nill, Ruth Flümann, Tobias Riet, Dinah Lange, Stuart J Blakemore, Herrad Baurmann, Conrad-Amadeus Voltin, Nicole Potter, Lilli Schlözer, Max Freihammer, Svenja Wagener-Ryczek, Andra-Iza Iuga, Jan-Michel Heger, Hanna Ludwig, Julia K Schleifenbaum, Jessica Propp, Paul J Bröckelmann, Ron D Jachimowicz, Gero Knittel, Sven Borchmann, Sabine Merkelbach-Bruse, Christian Pallasch, Martin Peifer, Jan Rybniker, Alexander Quaas, Mark Nitz, Johannes Brägelmann, Werner Müller, Thorsten Persigehl, Katarzyna Bozek, Sebastian J Theobald, Reinhard Büttner, Thomas Oellerich, Michael Hallek, Sebastian Kobold, Markus Chmielewski, Hans Christian Reinhardt, Crystal Mackall, Nima Abedpour, Peter Borchmann, Roland T Ullrich

Cancer Cell, 2025

Bispecific Nanosystems Enable Multieffector Immune Cell Retargeting for Hematologic Malignancy Therapy

Yefeng Shen, Xin Li, Jingnan Wu, Yuru Ma, Sven Borchmann, Zhenguo Cheng, Yaohe Wang, Yongliang Zhao, Jian Song, Boyu Luo, Xiuyun Liu, Yue Teng, Zhiyuan Shi

Adv Sci (Weinh), 2025

Human leukocyte antigen (HLA) class I expression on Hodgkin-Reed-Sternberg cells is an EBV-independent major determinant of microenvironment composition in classic Hodgkin lymphoma

Berit Müller-Meinhard, Nicole Seifert, Johanna Grund, Sarah Reinke, Fatih Yalcin, Helen Kaul, Sven Borchmann, Bastian von Tresckow, Peter Borchmann, Annette Plütschow, Julia Richter, Andreas Engert, Michael Altenbuchinger, Paul J Bröckelmann, Wolfram Klapper

Hemasphere, 2024

Multicenter development of a PET-based risk assessment tool for product-specific outcome prediction in large B-cell lymphoma patients undergoing CAR T-cell therapy

Conrad-Amadeus Voltin, Andrea Paccagnella, Michael Winkelmann, Jan-Michel Heger, Beatrice Casadei, Laura Beckmann, Ken Herrmann, Franziska J Dekorsy, Nadine Kutsch, Peter Borchmann, Stefano Fanti, Wolfgang G Kunz, Marion Subklewe, Carsten Kobe, Pier Luigi Zinzani, Matthias Stelljes, Katrin S Roth, Alexander Drzezga, Richard Noppeney, Kambiz Rahbar, H Christian Reinhardt, Bastian von Tresckow, Robert Seifert, Jörn C Albring, Viktoria Blumenberg, Andrea Farolfi, Sarah Flossdorf, Philipp Gödel, Christine Hanoun

Eur J Nucl Med Mol Imaging, 2024

Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA

Jan-Michel Heger, Julia Mattlener, Jessica Schneider, Philipp Gödel, Noëlle Sieg, Fabian Ullrich, Richard Ian Lewis, Teodora Bucaciuc-Mracica, Roland F. Schwarz, Daniel Rueß, Maximilian I Ruge, Manuel Montesinos-Rongen, Martina Deckert, Tobias Blau, Nadine Kutsch, Hyatt Balke-Want, Jonathan Weiss, Kerstin Becker, H. Christian Reinhardt, Michael Hallek, Peter Borchmann, Bastian von Tresckow, Sven Borchmann

Blood, 2024

Circulating Tumor DNA Sequencing for Biologic Classification and Individualized Risk Stratification in Patients With Hodgkin Lymphoma

Jan-Michel Heger, Laman Mammadova, Julia Mattlener, Sophia Sobesky, Melita Cirillo, Janine Altmüller, Elisabeth Kirst, Sarah Reinke, Wolfram Klapper, Paul J Bröckelmann, Justin Ferdinandus, Helen Kaul, Gundolf Schneider, Jessica Schneider, Julia Katharina Schleifenbaum, Roland T Ullrich, Max Freihammer, Sabine Awerkiew, Mia Lohmann, Florian Klein, Peter Nürnberg, Michael Hallek, Davide Rossi, Christine Mauz-Körholz, Stefan Gattenlöhner, Andreas Bräuninger, Peter Borchmann, Bastian von Tresckow, Sven Borchmann

J Clin Oncol, 2024

Noninvasive minimal residual disease assessment in relapsed/refractory large B-cell lymphoma using digital droplet PCR

Jan-Michel Heger, Yannick d'Hargues, Fanni Kleinert, Julia Mattlener, Jonathan Weiss, Fabian Franzen, Christian Becker, Kerstin Becker, Philipp Gödel, Marcel Schmiel, Jörn Meinel, Ruth Flümann, Florian Simon, H Christian Reinhardt, Peter Borchmann, Sven Borchmann, Hyatt Balke-Want, Gero Knittel, Bastian von Tresckow

Eur J Haematol, 2024

Outcome Prediction in Patients With Large B-cell Lymphoma Undergoing Chimeric Antigen Receptor T-cell Therapy

Conrad-Amadeus Voltin, Philipp Gödel, Laura Beckmann, Jan-Michel Heger, Carsten Kobe, Nadine Kutsch, Peter Borchmann, Markus Dietlein, Ken Herrmann, Matthias Stelljes, Kambiz Rahbar, Georg Lenz, H Christian Reinhardt, Marcel Teichert, Richard Noppeney, Jörn C Albring, Robert Seifert, Bastian von Tresckow, Sarah Flossdorf, Christine Hanoun

Hemasphere, 2023

Clinical applications of circulating tumor DNA in Hodgkin lymphoma

Jan-Michel Heger, Justin Ferdinandus, Julia Mattlener, Sven Borchmann

Semin Hematol, 2023

9p24.1 alterations and programmed cell death 1 ligand 1 expression in early stage unfavourable classical Hodgkin lymphoma: an analysis from the German Hodgkin Study Group NIVAHL trial

Elena Gerhard-Hartmann, Helen Goergen, Paul J Bröckelmann, Anja Mottok, Tabea Steinmüller, Johanna Grund, Alberto Zamò, Susana Ben-Neriah, Stephanie Sasse, Sven Borchmann, Michael Fuchs, Peter Borchmann, Sarah Reinke, Andreas Engert, Johanna Veldman, Arjan Diepstra, Wolfram Klapper, Andreas Rosenwald

Br J Haematol, 2022

Blood-based Monitoring of Relapsed/Refractory Hodgkin Lymphoma Patients Predict Responses to Anti-PD-1 Treatment

Esther E E Drees, Yvonne W S Jauw, Erik van Dijk, Sven Borchmann, Sandra A W M Verkuijlen, Phylicia Stathi, Nils J Groenewegen, Nathalie J Hijmering, Daniella R A I Berry, Eric J Meershoek, Danielle Hoogmoed, Anne Kwakman, Tessa J Molenaar, Dirk M Pegtel, Bauke Ylstra, Daphne de Jong, Josée M Zijlstra, Margaretha G M Roemer

Hemasphere, 2022

Coming of age: the evolving role of circulating tumor DNA in malignant lymphoma

Jan-Michel Heger, Sven Borchmann

Leuk Lymphoma, 2022

Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma

Maria A Garcia-Marquez, Martin Thelen, Sarah Reinke, Diandra Keller, Kerstin Wennhold, Jonas Lehmann, Johanna Veldman, Sven Borchmann, Andreas Rosenwald, Stephanie Sasse, Arjan Diepstra, Peter Borchmann, Andreas Engert, Wolfram Klapper, Michael von Bergwelt-Baildon, Paul J Bröckelmann, Hans A Schlößer

Leukemia, 2022

Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma

Maria Cristina Pirosa, Sven Borchmann, Fabrice Jardin, Gianluca Gaidano, Davide Rossi

Hemasphere, 2022

Tripartite antigen-agnostic combination immunotherapy cures established poorly immunogenic tumors

Sven Borchmann, Carolin Selenz, Mia Lohmann, Hanna Ludwig, Asmae Gassa, Johannes Brägelmann, Philipp Lohneis, Lydia Meder, Julia Mattlener, Sara Breid, Marieke Nill, Jana Fassunke, Amy J Wisdom, Anik Compes, Birgit Gathof, Hakan Alakus, David Kirsch, Khosro Hekmat, Reinhard Büttner, H Christian Reinhardt, Michael Hallek, Roland T Ullrich

J Immunother Cancer, 2022

An atlas of the tissue and blood metagenome in cancer reveals novel links between bacteria, viruses and cancer

Sven Borchmann

Microbiome, 2021

In-depth cell-free DNA sequencing reveals genomic landscape of Hodgkin's lymphoma and facilitates ultrasensitive residual disease detection

Sophia Sobesky, Laman Mammadova, Melita Cirillo, Esther E E Drees, Julia Mattlener, Helge Dörr, Janine Altmüller, Zhiyuan Shi, Paul J Bröckelmann, Jonathan Weiss, Stefanie Kreissl, Stephanie Sasse, Roland T Ullrich, Sarah Reinke, Wolfram Klapper, Elena Gerhard-Hartmann, Andreas Rosenwald, Margaretha G M Roemer, Peter Nürnberg, Anton Hagenbeek, Josée M Zijlstra, Dirk Michiel Pegtel, Andreas Engert, Peter Borchmann, Bastian von Tresckow, Sven Borchmann

Med, 2021

Liquid biopsy in Hodgkin lymphoma - moving beyond the proof of principle

Sven Borchmann

Br J Haematol, 2021

Liquid biopsy in lymphoma: Molecular methods and clinical applications

Melita Cirillo, Alexander F.M. Craig, Sven Borchmann, David M. Kurtz

Cancer Treat Rev, 2020

An update on disease biomarkers for Hodgkin lymphoma

Melita Cirillo, Sven Borchmann

Expert Rev Hematol, 2020

Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1

Sarah Reinke, Paul J Bröckelmann, Ingram Iaccarino, Maria Alejandra Garcia-Marquez, Sven Borchmann, Franziska Jochims, Michaela Kotrova, Karol Pal, Monika Brüggemann, Elena Hartmann, others

Blood, 2020