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Translational Research in Hodgkin Lymphoma


In close ties with the German Hodgkin Study Group (GHSG) we archive biomaterials from Hodgkin lymphoma patients within GHSG clinical trials. Building on this large collection of materials we are conducting translational studies to deepen our understanding of Hodgkin lymphoma biology. Exemplary, we have recently developed a biological classification of Hodgkin lymphoma based on circulating tumor DNA sequencing.
Building on that, we are further investigating how these subtypes differ in terms of clinical and tumor microenvironmental features. Additionally, we are investigating various biomarkers that might help to 
to identify Hodgkin lymphoma patients who might exceptionally benefit from checkpoint inhibition

Publications


Rapid molecular response kinetics to anti-PD-1-based first-line treatment of Hodgkin lymphoma in the GHSG NIVAHL trial


Jan-Michel Heger, Julia Mattlener, Peter Herhaus, Julia Meissner, Karolin Trautmann-Grill, Conrad-Amadeus Voltin, Jessica Schneider, Julia K Schleifenbaum, Sophie Heidenreich, Carsten Kobe, Helen Kaul, Wolfram Klapper, Bastian von Tresckow, Peter Borchmann, Paul J Bröckelmann, Sven Borchmann

Blood Adv, 2026


The genomic and clinical consequences of replacing procarbazine with dacarbazine in escalated BEACOPP for Hodgkin lymphoma: a retrospective, observational study


Anna Santarsieri, Emily Mitchell, My H Pham, Rashesh Sanghvi, Janina Jablonski, Henry Lee-Six, Katherine Sturgess, Pauline Brice, Tobias F Menne, Wendy Osborne, Thomas Creasey, Kirit M Ardeshna, Joanna Baxter, Sarah Behan, Kaljit Bhuller, Stephen Booth, Nikesh D Chavda, Graham P Collins, Dominic J Culligan, Kate Cwynarski, Andrew Davies, Abigail Downing, David Dutton, Michelle Furtado, Eve Gallop-Evans, Andrew Hodson, David Hopkins, Hannah Hsu, Sunil Iyengar, Stephen G Jones, Mamatha Karanth, Kim M Linton, Oliver C Lomas, Nicolas Martinez-Calle, Abhinav Mathur, Pamela McKay, Sateesh K Nagumantry, Elizabeth H Phillips, Neil Phillips, John F Rudge, Nimish K Shah, Gwyneth Stafford, Alex Sternberg, Rachel Trickey, Benjamin J Uttenthal, Natasha Wetherall, Xiao-Yin Zhang, Andrew K McMillan, Nicholas Coleman, Michael R Stratton, Elisa Laurenti, Peter Borchmann, Sven Borchmann, Peter J Campbell, Raheleh Rahbari, George A Follows

Lancet Oncol, 2025


Human leukocyte antigen (HLA) class I expression on Hodgkin-Reed-Sternberg cells is an EBV-independent major determinant of microenvironment composition in classic Hodgkin lymphoma


Berit Müller-Meinhard, Nicole Seifert, Johanna Grund, Sarah Reinke, Fatih Yalcin, Helen Kaul, Sven Borchmann, Bastian von Tresckow, Peter Borchmann, Annette Plütschow, Julia Richter, Andreas Engert, Michael Altenbuchinger, Paul J Bröckelmann, Wolfram Klapper

Hemasphere, 2024


Circulating Tumor DNA Sequencing for Biologic Classification and Individualized Risk Stratification in Patients With Hodgkin Lymphoma


Jan-Michel Heger, Laman Mammadova, Julia Mattlener, Sophia Sobesky, Melita Cirillo, Janine Altmüller, Elisabeth Kirst, Sarah Reinke, Wolfram Klapper, Paul J Bröckelmann, Justin Ferdinandus, Helen Kaul, Gundolf Schneider, Jessica Schneider, Julia Katharina Schleifenbaum, Roland T Ullrich, Max Freihammer, Sabine Awerkiew, Mia Lohmann, Florian Klein, Peter Nürnberg, Michael Hallek, Davide Rossi, Christine Mauz-Körholz, Stefan Gattenlöhner, Andreas Bräuninger, Peter Borchmann, Bastian von Tresckow, Sven Borchmann

J Clin Oncol, 2024


Clinical applications of circulating tumor DNA in Hodgkin lymphoma


Jan-Michel Heger, Justin Ferdinandus, Julia Mattlener, Sven Borchmann

Semin Hematol, 2023


9p24.1 alterations and programmed cell death 1 ligand 1 expression in early stage unfavourable classical Hodgkin lymphoma: an analysis from the German Hodgkin Study Group NIVAHL trial


Elena Gerhard-Hartmann, Helen Goergen, Paul J Bröckelmann, Anja Mottok, Tabea Steinmüller, Johanna Grund, Alberto Zamò, Susana Ben-Neriah, Stephanie Sasse, Sven Borchmann, Michael Fuchs, Peter Borchmann, Sarah Reinke, Andreas Engert, Johanna Veldman, Arjan Diepstra, Wolfram Klapper, Andreas Rosenwald

Br J Haematol, 2022


Blood-based Monitoring of Relapsed/Refractory Hodgkin Lymphoma Patients Predict Responses to Anti-PD-1 Treatment


Esther E E Drees, Yvonne W S Jauw, Erik van Dijk, Sven Borchmann, Sandra A W M Verkuijlen, Phylicia Stathi, Nils J Groenewegen, Nathalie J Hijmering, Daniella R A I Berry, Eric J Meershoek, Danielle Hoogmoed, Anne Kwakman, Tessa J Molenaar, Dirk M Pegtel, Bauke Ylstra, Daphne de Jong, Josée M Zijlstra, Margaretha G M Roemer

Hemasphere, 2022


Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma


Maria A Garcia-Marquez, Martin Thelen, Sarah Reinke, Diandra Keller, Kerstin Wennhold, Jonas Lehmann, Johanna Veldman, Sven Borchmann, Andreas Rosenwald, Stephanie Sasse, Arjan Diepstra, Peter Borchmann, Andreas Engert, Wolfram Klapper, Michael von Bergwelt-Baildon, Paul J Bröckelmann, Hans A Schlößer

Leukemia, 2022


Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1


Sarah Reinke, Paul J Bröckelmann, Ingram Iaccarino, Maria Alejandra Garcia-Marquez, Sven Borchmann, Franziska Jochims, Michaela Kotrova, Karol Pal, Monika Brüggemann, Elena Hartmann, others

Blood, 2020


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